The endocannabinoid system in renal cells: regulation of Na(+) transport by CB1 receptors through distinct cell signalling pathways.

@article{Sampaio2015TheES,
  title={The endocannabinoid system in renal cells: regulation of Na(+) transport by CB1 receptors through distinct cell signalling pathways.},
  author={Luzia da Silva Sampaio and R Taveira Da Silva and Diogo B. Lima and Cynthia Lima Sampaio and Fabio Arturo Iannotti and Enrico Mazzarella and Vincenzo Di Marzo and Adalberto Ramon Vieyra and Ricardo A. M. Reis and M Einicker-Lamas},
  journal={British journal of pharmacology},
  year={2015},
  volume={172 19},
  pages={
          4615-25
        }
}
BACKGROUND AND PURPOSE The function of the endocannabinoid system (ECS) in renal tissue is not completely understood. Kidney function is closely related to ion reabsorption in the proximal tubule, the nephron segment responsible for the re-absorption of 70-80% of the filtrate. We studied the effect of compounds modulating the activity of cannabinoid (CB) receptors on the active re-absorption of Na(+) in LLC-PK1 cells. EXPERIMENTAL APPROACH Changes in Na(+) /K(+) -ATPase activity were assessed… CONTINUE READING
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