The endocannabinoid system drives neural progenitor proliferation

@article{Aguado2005TheES,
  title={The endocannabinoid system drives neural progenitor proliferation},
  author={T. Aguado and K. Monory and J. Palazuelos and N. Stella and B. Cravatt and B. Lutz and G. Marsicano and Z. Kokaia and M. Guzm{\'a}n and I. Galve-Roperh},
  journal={The FASEB Journal},
  year={2005},
  volume={19}
}
The discovery of multipotent neural progenitor (NP) cells has provided strong support for the existence of neurogenesis in the adult brain. However, the signals controlling NP proliferation remain elusive. Endocannabinoids, the endogenous counterparts of marijuana‐derived cannabinoids, act as neuromodulators via presynaptic CB1 receptors and also control neural cell death and survival. Here we show that progenitor cells express a functional endocannabinoid system that actively regulates cell… Expand
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