The endocannabinoid system drives neural progenitor proliferation

  title={The endocannabinoid system drives neural progenitor proliferation},
  author={Tania Aguado and Krisztina Monory and Javier Palazuelos and Nephi Stella and Benjamin F. Cravatt and Beat Lutz and Giovanni Marsicano and Zaal Kokaia and Manuel Guzm{\'a}n and Ismael Galve-Roperh},
  journal={The FASEB Journal},
The discovery of multipotent neural progenitor (NP) cells has provided strong support for the existence of neurogenesis in the adult brain. However, the signals controlling NP proliferation remain elusive. Endocannabinoids, the endogenous counterparts of marijuana‐derived cannabinoids, act as neuromodulators via presynaptic CB1 receptors and also control neural cell death and survival. Here we show that progenitor cells express a functional endocannabinoid system that actively regulates cell… 
The Endocannabinoid System Promotes Astroglial Differentiation by Acting on Neural Progenitor Cells
It is shown that the CB1 receptor and the endocannabinoid-inactivating enzyme fatty acid amide hydrolase are expressed, both in vitro and in vivo, in postnatal radial glia (RC2+ cells) and in adult nestin type I (nestin+GFAP+) neural progenitor cells.
Regulation of neural progenitor cell fate by anandamide.
Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development.
New observations support that eCBs constitute a new family of lipid signaling cues responsible for the regulation of neural progenitor proliferation and differentiation, acting as instructive proliferative signals through the CB1 receptor.
Endocannabinoids via CB1 receptors act as neurogenic niche cues during cortical development
Findings provide the rationale for understanding better the consequences of prenatal cannabinoid exposure, and emphasize a novel role of ECBs as neurogenic instructive cues involved in cortical development.
Endocannabinoids Regulate the Migration of Subventricular Zone-Derived Neuroblasts in the Postnatal Brain
A novel role for the endocannabinoid system is described in neuroblast migration in vivo, highlighting its importance in regulating an additional essential step in adult neurogenesis.
The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders
Significant implications of new findings, such as the participation of the endocannabinoid system in the pathogenesis of neurodevelopmental disorders and the regulation of neurogenesis in brain depression, are discussed herein.
Cannabinoid Receptor Modulation of Neurogenesis: ST14A Striatal Neural Progenitor Cells as a Simplified In Vitro Model
ST14A neural progenitor cells are proposed as a useful in vitro model for studying ECS modulation of neurogenesis, also in prospective in vivo pharmacological studies.
The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis*
The results show the involvement of the CB1 cannabinoid receptor in NP proliferation and neurogenesis induced by excitotoxic injury and support a role for bFGF signaling in this process.
The role of cannabinoids in adult neurogenesis
This timely review summarizes the evidence that the cannabinoid system is intricately associated with neuronal differentiation and maturation of NPCs and highlights intrinsic/extrinsic signalling mechanisms that are cannabinoid targets.


The Endocannabinoid Anandamide Inhibits Neuronal Progenitor Cell Differentiation through Attenuation of the Rap1/B-Raf/ERK Pathway*
The data indicate that endocannabinoids inhibit neuronal progenitor cell differentiation through attenuation of the ERK pathway and suggest that they constitute a new physiological system involved in the regulation of neurogenesis.
Cannabinoids Promote Oligodendrocyte Progenitor Survival: Involvement of Cannabinoid Receptors and Phosphatidylinositol-3 Kinase/Akt Signaling
Oligodendrocyte progenitors undergo apoptosis with the withdrawal of trophic support, and both the selective CB1 agonist arachidonyl-2′-chloroethylamide/(all Z)-N-(2-cycloethyl)-5,8,11,14-eicosatetraenamide and the nonselective cannabinoid agonists HU210 and (+)-Win-55212-2 enhanced cell survival.
The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response
In rat cerebellar granule neurons, CB1 cannabinoid receptor antagonists inhibit axonal growth responses stimulated by N-cadherin and FGF2.
Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway*
Results show that cannabinoids protect astrocytes from ceramide-induced apoptosis via stimulation of the phosphatidylinositol 3-kinase/protein kinase B pathway, the first evidence for an “astroprotective” role of cannabinoids.
The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis
The involvement of AEA in apoptosis and the underlying signal transduction pathways will be reviewed, along with the metabolic routes and the molecular targets of this endocannabinoid.
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
It is shown that intratumoral administration of Δ9-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2.
Neurogenesis in the adult brain: new strategies for central nervous system diseases.
Current understanding of the mechanisms controlling adult neurogenesis are summarized and their implications for the development of new strategies for the treatment of neurodegenerative diseases are discussed.
Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.
CB1 and VR1 receptors both seem to have roles in regulating adult neurogenesis.
The “Dark Side” of Endocannabinoids: A Neurotoxic Role for Anandamide
  • I. Cernak, R. Vink, A. Faden
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2004
It is shown that anandamide causes neuronal cell death in vitro and exacerbates cell loss caused by stretch-induced axonal injury or trophic withdrawal in rat primary neuronal cultures.
Neural stem and progenitor cells in nestin‐GFP transgenic mice
The results indicate that GFP‐positive cells in transgenic animals accurately represent neural stem and progenitor cells and suggest that these nestin‐GFP–expressing cells encompass the majority of the neural stem cells in the adult brain.