The endocannabinoid system drives neural progenitor proliferation.

  title={The endocannabinoid system drives neural progenitor proliferation.},
  author={Tania Aguado and Krisztina Monory and Javier Palazuelos and Nephi Stella and Benjamin F Cravatt and Beat Lutz and Giovanni Marsicano and Zaal Kokaia and M {\'A}ngeles Guzm{\'a}n and Ismael Galve-Roperh},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={19 12},
The discovery of multipotent neural progenitor (NP) cells has provided strong support for the existence of neurogenesis in the adult brain. However, the signals controlling NP proliferation remain elusive. Endocannabinoids, the endogenous counterparts of marijuana-derived cannabinoids, act as neuromodulators via presynaptic CB1 receptors and also control neural cell death and survival. Here we show that progenitor cells express a functional endocannabinoid system that actively regulates cell… CONTINUE READING
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Milestones of Page 7 of 14 (page number not for citation purposes) neuronal development in the adult hippocampus

  • G. Kempermann, S. Jessberg, B. Steiner, G. Kronenberg
  • Trends Neurosci
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