The endocannabinoid system and the brain.

@article{Mechoulam2013TheES,
  title={The endocannabinoid system and the brain.},
  author={Raphael Mechoulam and Linda A. Parker},
  journal={Annual review of psychology},
  year={2013},
  volume={64},
  pages={
          21-47
        }
}
The psychoactive constituent in cannabis, Δ(9)-tetrahydrocannabinol (THC), was isolated in the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous cannabinoids (anandamide and 2-arachidonoyl glycerol) were identified only 20 to 25 years later. The cannabinoid system affects both central nervous system (CNS) and peripheral processes. In this review, we have tried to summarize research--with an emphasis on recent publications--on the actions of the endocannabinoid… Expand
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