The endocannabinoid system and pain.

@article{Guindon2009TheES,
  title={The endocannabinoid system and pain.},
  author={Jos{\'e}e Guindon and Andrea G. Hohmann},
  journal={CNS \& neurological disorders drug targets},
  year={2009},
  volume={8 6},
  pages={
          403-21
        }
}
The therapeutic potential of cannabinoids has been the topic of extensive investigation following the discovery of cannabinoid receptors and their endogenous ligands. Cannabinoid receptors and their endogenous ligands are present at supraspinal, spinal and peripheral levels. Cannabinoids suppress behavioral responses to noxious stimulation and suppress nociceptive processing through activation of cannabinoid CB(1) and CB(2) receptor subtypes. Endocannabinoids, the brain's own cannabis-like… 

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