The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation.

@article{Marzo2009TheES,
  title={The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation.},
  author={Vincenzo Di Marzo},
  journal={Pharmacological research},
  year={2009},
  volume={60 2},
  pages={77-84}
}
The endocannabinoid signalling system includes: (1) at least two G-protein-coupled receptors, known as the cannabinoid CB(1) and CB(2) receptors and discovered following studies on the mechanism of action of Delta(9)-tetrahydrocannabinol, the major psychoactive principle of the hemp plant Cannabis sativa; (2) the endogenous agonists at these receptors, known as endocannabinoids, of which anandamide and 2-arachidonoylglycerol are the best known; and (3) proteins and enzymes for the regulation of… CONTINUE READING
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