The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice.

@article{Wilkerson2017TheEH,
  title={The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice.},
  author={Jenny L Wilkerson and Sudeshna Ghosh and Mohammed A. Mustafa and Rehab A. Abdullah and Micah J. Niphakis and R. Herruzo. Cabrera and Rafael Maldonado and Benjamin F Cravatt and Aron H. Lichtman},
  journal={Neuropharmacology},
  year={2017},
  volume={114},
  pages={
          156-167
        }
}
Although opioids are highly efficacious analgesics, their abuse potential and other untoward side effects diminish their therapeutic utility. The addition of non-opioid analgesics offers a promising strategy to reduce required antinociceptive opioid doses that concomitantly reduce opioid-related side effects. Inhibitors of the primary endocannabinoid catabolic enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) show opioid-sparing effects in preclinical models of pain… CONTINUE READING
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Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model

N. S. Adamson Barnes, V. A. Mitchell, N. P. Kazantzis, C. W. Vaughan
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