The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors.

@article{Baldassarri2008TheE2,
  title={The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors.},
  author={Samantha Baldassarri and Alessandra Bertoni and Alessandra Bagarotti and Chiara Sarasso and Manuela Zanfa and Maria Valeria Catani and Luciana Avigliano and Mauro Maccarrone and Mauro Torti and Fabiola Sinigaglia},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2008},
  volume={6 10},
  pages={1772-9}
}
BACKGROUND The endocannabinoid 2-arachidonoylglycerol (2-AG) is an endogenous lipid that acts through the activation of G-protein-coupled cannabinoid receptors and plays essential roles in many physiological contexts. In the cardiovascular system 2-AG is generated by both activated endothelial cells and platelets, and participates in the regulation of inflammation and thrombosis. Although human platelets actively metabolize endocannabinoids, 2-AG also binds to platelet surface and leads to cell… CONTINUE READING
16 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…