The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells.

@article{Wilhelmsen2014TheEN,
  title={The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells.},
  author={Kevin Wilhelmsen and Samira Khakpour and Alphonso Tran and Kayla Sheehan and Mark Schumacher and Fengyun Xu and Judith Hellman},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 19},
  pages={13079-100}
}
Although cannabinoids, such as Δ(9)-tetrahydrocannabinol, have been studied extensively for their psychoactive effects, it has become apparent that certain cannabinoids possess immunomodulatory activity. Endothelial cells (ECs) are centrally involved in the pathogenesis of organ injury in acute inflammatory disorders, such as sepsis, because they express cytokines and chemokines, which facilitate the trafficking of leukocytes to organs, and they modulate vascular barrier function. In this study… CONTINUE READING
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