The end of a monolith: Deconstructing the Cnn-Polo interaction

@article{Eisman2016TheEO,
  title={The end of a monolith: Deconstructing the Cnn-Polo interaction},
  author={R. Eisman and Melissa Phelps and T. Kaufman},
  journal={Fly},
  year={2016},
  volume={10},
  pages={60 - 72}
}
ABSTRACT In Drosophila melanogaster a functional pericentriolar matrix (PCM) at mitotic centrosomes requires Centrosomin-Long Form (Cnn-LF) proteins. Moreover, tissue culture cells have shown that the centrosomal localization of both Cnn-LF and Polo kinase are co-dependent, suggesting a direct interaction. Our recent study found Cnn potentially binds to and is phosphorylated by Polo kinase at 2 residues encoded by Exon1A, the initiating exon of a subset of Cnn isoforms. These interactions are… Expand
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The Centrioles, Centrosomes, Basal Bodies, and Cilia of Drosophila melanogaster

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