The end adjusts the means: Heterochromatin remodelling during terminal cell differentiation

@article{Grigoryev2005TheEA,
  title={The end adjusts the means: Heterochromatin remodelling during terminal cell differentiation},
  author={Sergei A Grigoryev and Yaroslava A. Bulynko and Evgenya Y Popova},
  journal={Chromosome Research},
  year={2005},
  volume={14},
  pages={53-69}
}
All cells that constitute mature tissues in an eukaryotic organism undergo a multistep process of cell differentiation. At the terminal stage of this process, cells either cease to proliferate forever or rest for a very long period of time. During terminal differentiation, most of the genes that are required for cell ‘housekeeping’ functions, such as proto-oncogenes and other cell-cycle and cell proliferation genes, become stably repressed. At the same time, nuclear chromatin undergoes dramatic… Expand
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