The emerging roles of serine protease cascades in the epidermis.

  title={The emerging roles of serine protease cascades in the epidermis.},
  author={Petra Ovaere and Saskia Lippens and Peter Vandenabeele and Wim Declercq},
  journal={Trends in biochemical sciences},
  volume={34 9},
It has become clear in recent years that serine proteases have an important role in epidermal homeostasis, and the signaling cascades are gradually being identified. For example, matriptase, prostasin and furin are implicated in a cascade that could activate ENaC, leading to epidermal barrier formation and hydration, probably in part through their involvement in filaggrin processing. Kallikreins can form a signaling cascade to coordinate corneocyte desquamation. Knowledge is also emerging about… CONTINUE READING