The emerging role of the LIV-1 subfamily of zinc transporters in breast cancer.

@article{Taylor2007TheER,
  title={The emerging role of the LIV-1 subfamily of zinc transporters in breast cancer.},
  author={Kathryn M Taylor and Helen E Morgan and Kathryn Smart and Normawati M Zahari and Sara L Pumford and Ian O. Ellis and John F. R. Robertson and Robert Ian Nicholson},
  journal={Molecular medicine},
  year={2007},
  volume={13 7-8},
  pages={
          396-406
        }
}
Zinc transporter LIV-1 (SLC39A6) is estrogen regulated and present in increased amounts in estrogen receptor-positive breast cancer as well as in tumors that spread to the lymph nodes. The LIV-1 subfamily of ZIP zinc transporters consists of nine human sequences that share considerable homology across transmembrane domains. Many of these sequences have been shown to transport zinc and/or other ions across cell membranes. Increasingly, studies have implicated members of the LIV-1 transporter… CONTINUE READING
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