The emerging role of the CTLA-4 gene in autoimmune endocrinopathies.

  title={The emerging role of the CTLA-4 gene in autoimmune endocrinopathies.},
  author={Bijay Vaidya and Simon H. S. Pearce},
  journal={European journal of endocrinology},
  volume={150 5},
It is thought that the majority of autoimmune endocrinopathies, including Graves' disease, autoimmune hypothyroidism, type 1 diabetes mellitus and autoimmune Addison's disease (sporadic and as well as autoimmune polyendocrinopathy syndrome type 2) are inherited as complex genetic traits. Multiple genetic and environmental factors interact with each other to confer susceptibility to these disorders. In recent years there have been considerable efforts towards defining susceptibility genes for… CONTINUE READING