The emerging role of targeting cancer metabolism for cancer therapy

@article{Farhadi2020TheER,
  title={The emerging role of targeting cancer metabolism for cancer therapy},
  author={Pegah Farhadi and Reza Yarani and Sadat Dokaneheifard and Kamran Mansouri},
  journal={Tumor Biology},
  year={2020},
  volume={42}
}
Glucose, as the main consuming nutrient of the body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce different glucose-derived metabolites and thus affect cells’ bioenergetics differently. Tumor cells’ dependency to aerobic glycolysis and other cancer-specific metabolism changes are known as the cancer hallmarks, distinct cancer cells from normal cells. Therefore, these tumor-specific characteristics receive the limelight… Expand
View on SAGE
journals.sagepub.com
8 Citations
Background Citations
4

Figures from this paper

8 Citations

Citation Type

Citation Type

1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia
TLDR
Recent studies have shown that in response to glutamine deprivation leukemia cells upregulate key enzymes in the serine biosynthesis pathway, suggesting that serine upregulation may be a targetable compensatory mechanism. Expand
Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases
TLDR
It is proposed that melatonin’s function as a glycolytic explains its actions in inhibiting a variety of diseases and the common denominator is melatonin's action in switching the metabolic phenotype of cells. Expand
Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment
TLDR
A perspective is provided on how a more detailed understanding of the unique metabolic interdependency between Th2 cells and the TME could reveal novel avenues for the development of immunotherapies in treating cancer. Expand
miR-183-5p Promotes HCC Migration/Invasion via Increasing Aerobic Glycolysis
  • Y. Niu, Fang Liu, +5 authors Che Chen
  • Medicine
  • OncoTargets and therapy
  • 2021
TLDR
Findings suggest that miR-183-5p may promote HCC migration and invasion via increasing aerobic glycolysis through targeting PTEN and then activating Akt/mTOR signaling. Expand
Loss of the redox mitochondrial protein mitoNEET leads to mitochondrial dysfunction in B-cell acute lymphoblastic leukemia.
TLDR
Observations suggest that mitoNEET is essential for optimal function of mitochondria in B-cell ALL and may represent a novel anti-leukemic drug target for treatment of minimal residual disease. Expand
Interfering with Tumor Hypoxia for Radiotherapy Optimization
TLDR
The main hypoxia-related processes relevant for radiotherapy on the subcellular, cellular and tissue level are summarized and the significance of Hypoxia in radiation oncology is discussed, especially with regard to the current shift towards hypofractionated treatment regimens. Expand
Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells
TLDR
The current article overviews the state-of-the-art knowledge regarding the mitochondrial functions of endogenously produced H2S in cancer cells. Expand
Circadian clock synchrony and chronotherapy opportunities in cancer treatment.
TLDR
Advances and challenges in cancer biology as a function of time of day are highlighted, indicating that personalized medicine should include understanding and accounting for daily rhythms in cancer patients. Expand

References

SHOWING 1-10 OF 249 REFERENCES
Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism
TLDR
This graphical review will be useful in helping undergraduate, graduate, and medical students understand how investigating the basics of cancer cell metabolism could provide new insight in developing potentially new anticancer treatment strategies. Expand
The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy
TLDR
The role of Snail (Snai1), an important regulator of the epithelial mesenchymal transition (EMT), in controlling glucose flux towards PPP and thus potentiating cancer cell survival under oxidative and metabolic stress is summarized. Expand
Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?
TLDR
Inhibition of PDKs could be an attractive therapeutic approach for the development of anti-cancer drugs because of their role as regulator of PDC that catalyzes the oxidative decarboxylation of pyruvate in mitochondrion. Expand
Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer
TLDR
Recent advances in the development of chemotherapeutic agents against several metabolic targets for cancer therapy are covered, including glucose transporters, hexokinase, pyruvate kinase M2, glutaminase, and isocitrate dehydrogenase. Expand
Oxidative Phosphorylation as an Emerging Target in Cancer Therapy
TLDR
Novel applications of OXPHOS inhibitors with a suitable therapeutic index to target cancer cell metabolism are highlighted and several drugs including metformin, atovaquone, and arsenic trioxide are used clinically for non-oncologic indications, but emerging data demonstrate their potential use as OXPI inhibitors. Expand
Cancer cells change their glucose metabolism to overcome increased ROS: One step from cancer cell to cancer stem cell?
TLDR
It is hypothesized that in cancer cells this metabolic deviation during persistent oxidative stress might be a sign of cancer cells' shift towards CSCs, an issue that might be pivotal in more effective targeting ofcancer cells and C SCs. Expand
Cancer metabolism: a therapeutic perspective
TLDR
How cancer cells reprogramme their metabolism and that of other cells within the tumour microenvironment in order to survive and propagate, thus driving disease progression is discussed; in particular, potential metabolic vulnerabilities that might be targeted therapeutically are highlighted. Expand
Monocarboxylate transporters in cancer
TLDR
This review summarizes the current knowledge about MCT structure, regulation and functions in cancer, with a specific focus on lactate metabolism, lactate-induced angiogenesis and MCT-dependent cancer metastasis, and describes lactate signaling via cell surface lactate receptor GPR81. Expand
Defining the Molecular Basis of Tumor Metabolism: a Continuing Challenge Since Warburg’s Discovery
Cancer cells are the product of genetic disorders that alter crucial intracellular signaling pathways associated with the regulation of cell survival, proliferation, differentiation and death… Expand
Regulation of the pentose phosphate pathway in cancer
TLDR
A better understanding of how the PPP is reprogrammed and the mechanism underlying the balance between glycolysis and PPP flux in cancer will be valuable in developing therapeutic strategies targeting this pathway. Expand
...
1
2
3
4
5
...