The emerging role of targeting cancer metabolism for cancer therapy

@article{Farhadi2020TheER,
  title={The emerging role of targeting cancer metabolism for cancer therapy},
  author={Pegah Farhadi and Reza Yarani and Sadat Dokaneheifard and Kamran Mansouri},
  journal={Tumor Biology},
  year={2020},
  volume={42}
}
Glucose, as the main consuming nutrient of the body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce different glucose-derived metabolites and thus affect cells’ bioenergetics differently. Tumor cells’ dependency to aerobic glycolysis and other cancer-specific metabolism changes are known as the cancer hallmarks, distinct cancer cells from normal cells. Therefore, these tumor-specific characteristics receive the limelight… 
View on SAGE
journals.sagepub.com
16 Citations
Background Citations
7

Figures from this paper

16 Citations

Citation Type

Citation Type

Cell line-directed breast cancer research based on glucose metabolism status.
1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia
TLDR
Recent studies have shown that in response to glutamine deprivation leukemia cells upregulate key enzymes in the serine biosynthesis pathway, suggesting that serine upregulation may be a targetable compensatory mechanism.
Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases
TLDR
It is proposed that melatonin’s function as a glycolytic explains its actions in inhibiting a variety of diseases and the common denominator is melatonin's action in switching the metabolic phenotype of cells.
Butyrate and Metformin Affect Energy Metabolism Independently of the Metabolic Phenotype in the Tumor Therapy Model
TLDR
The BALB-TTM is a relevant model for mechanistic cancer research, and the generation of monoclonal cell lines offers a novel possibility to investigate specific drug effects in a heterogeneous tumor cell population, as well as indicating that induced alterations in energy metabolism seem to be independent of the original metabolic phenotype.
Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment
TLDR
A perspective is provided on how a more detailed understanding of the unique metabolic interdependency between Th2 cells and the TME could reveal novel avenues for the development of immunotherapies in treating cancer.
Emerging Role of TCA Cycle-Related Enzymes in Human Diseases
TLDR
This review aims to provide a comprehensive overview of the relationship between each TCA cycle-related enzyme and human diseases, and discusses their functions in the context of both mitochondrial and extra-mitochondrial enzymes.
miR-183-5p Promotes HCC Migration/Invasion via Increasing Aerobic Glycolysis
TLDR
Findings suggest that miR-183-5p may promote HCC migration and invasion via increasing aerobic glycolysis through targeting PTEN and then activating Akt/mTOR signaling.
Loss of the redox mitochondrial protein mitoNEET leads to mitochondrial dysfunction in B-cell acute lymphoblastic leukemia.
Interfering with Tumor Hypoxia for Radiotherapy Optimization
TLDR
The main hypoxia-related processes relevant for radiotherapy on the subcellular, cellular and tissue level are summarized and the significance of Hypoxia in radiation oncology is discussed, especially with regard to the current shift towards hypofractionated treatment regimens.
A Resource to Infer Molecular Paths Linking Cancer Mutations to Perturbation of Cell Metabolism
TLDR
This work refined a recently developed graph analysis tool that permits users to infer causal paths leading from any human gene to modulation of metabolic pathways, and identified likely functional paths offering a rational framework for exploring new therapeutic strategies that revert the disease phenotype.
...
...

References

SHOWING 1-10 OF 230 REFERENCES
Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism
The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy
TLDR
The role of Snail (Snai1), an important regulator of the epithelial mesenchymal transition (EMT), in controlling glucose flux towards PPP and thus potentiating cancer cell survival under oxidative and metabolic stress is summarized.
Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?
TLDR
Inhibition of PDKs could be an attractive therapeutic approach for the development of anti-cancer drugs because of their role as regulator of PDC that catalyzes the oxidative decarboxylation of pyruvate in mitochondrion.
Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer
TLDR
Recent advances in the development of chemotherapeutic agents against several metabolic targets for cancer therapy are covered, including glucose transporters, hexokinase, pyruvate kinase M2, glutaminase, and isocitrate dehydrogenase.
Oxidative Phosphorylation as an Emerging Target in Cancer Therapy
TLDR
Novel applications of OXPHOS inhibitors with a suitable therapeutic index to target cancer cell metabolism are highlighted and several drugs including metformin, atovaquone, and arsenic trioxide are used clinically for non-oncologic indications, but emerging data demonstrate their potential use as OXPI inhibitors.
Cancer metabolism: a therapeutic perspective
TLDR
How cancer cells reprogramme their metabolism and that of other cells within the tumour microenvironment in order to survive and propagate, thus driving disease progression is discussed; in particular, potential metabolic vulnerabilities that might be targeted therapeutically are highlighted.
Cancer cells change their glucose metabolism to overcome increased ROS: One step from cancer cell to cancer stem cell?
Monocarboxylate transporters in cancer
Regulation of the pentose phosphate pathway in cancer
TLDR
A better understanding of how the PPP is reprogrammed and the mechanism underlying the balance between glycolysis and PPP flux in cancer will be valuable in developing therapeutic strategies targeting this pathway.
Defining the Molecular Basis of Tumor Metabolism: a Continuing Challenge Since Warburg’s Discovery
TLDR
T tumor metabolism is still only partly understood and the metabolic aspects of transformation constitute a major challenge for science, Nevertheless, cancer metabolism can be exploited to devise novel avenues for the rational treatment of this disease.
...
...