The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders

@article{Betancur2009TheER,
  title={The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders},
  author={Catalina Betancur and Takeshi Sakurai and Joseph D. Buxbaum},
  journal={Trends in Neurosciences},
  year={2009},
  volume={32},
  pages={402-412}
}
Recent advances in genetics and genomics have unveiled numerous cases of autism spectrum disorders (ASDs) associated with rare, causal genetic variations. These findings support a novel view of ASDs in which many independent, individually rare genetic variants, each associated with a very high relative risk, together explain a large proportion of ASDs. Although these rare variants impact diverse pathways, there is accumulating evidence that synaptic pathways, including those involving synaptic… 
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