The emerging role of splicing factors in cancer.

  title={The emerging role of splicing factors in cancer.},
  author={Ana Rita Fialho Grosso and Sandra Marina Martins and Maria Carmo-Fonseca},
  journal={EMBO reports},
  volume={9 11},
Recent progress in global sequence and microarray data analysis has revealed the increasing complexity of the human transcriptome. Alternative splicing generates a huge diversity of transcript variants and disruption of splicing regulatory networks is emerging as an important contributor to various diseases, including cancer. Current efforts to establish the dynamic repertoire of transcripts that are generated in health and disease are showing that many cancer-associated alternative-splicing… CONTINUE READING