The emerging role of phosphate in vascular calcification.

  title={The emerging role of phosphate in vascular calcification.},
  author={Cecilia M. Giachelli},
  journal={Kidney international},
  volume={75 9},
Vascular calcification is recognized as a major contributor to cardiovascular disease (CVD) in end stage renal disease (ESRD) patients. Susceptibility to vascular calcification is genetically determined and actively regulated by diverse inducers and inhibitors. One of these inducers, hyperphosphatemia, promotes vascular calcification and is a nontraditional risk factor for CVD mortality in ESRD patients. Vascular smooth muscle cells (SMCs) respond to elevated phosphate levels by undergoing an… CONTINUE READING