The emerging role of forces in axonal elongation.

  title={The emerging role of forces in axonal elongation.},
  author={Daniel M Suter and Kyle E. Miller},
  journal={Progress in neurobiology},
  volume={94 2},
An understanding of how axons elongate is needed to develop rational strategies to treat neurological diseases and nerve injury. Growth cone-mediated neuronal elongation is currently viewed as occurring through cytoskeletal dynamics involving the polymerization of actin and tubulin subunits at the tip of the axon. However, recent work suggests that axons and growth cones also generate forces (through cytoskeletal dynamics, kinesin, dynein, and myosin), forces induce axonal elongation, and axons… CONTINUE READING


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