The emerging role of endothelin-1 in the pathogenesis of pre-eclampsia.

  title={The emerging role of endothelin-1 in the pathogenesis of pre-eclampsia.},
  author={L Saleh and Koen Verdonk and Willy Visser and Anton H. van den Meiracker and A. H. Jan Danser},
  journal={Therapeutic advances in cardiovascular disease},
  volume={10 5},
Pre-eclampsia (PE) is the most frequently encountered medical complication during pregnancy. It is characterized by a rise in systemic vascular resistance with a relatively low cardiac output and hypovolemia, combined with severe proteinuria. Despite the hypovolemia, renin-angiotensin system (RAS) activity is suppressed and aldosterone levels are decreased to the same degree as renin. This suggests that the RAS is not the cause of the hypertension in PE, but rather that its suppression is the… CONTINUE READING
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