The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings.

  title={The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings.},
  author={David Andrew Martin and Jennifer E Towne and Gregory Kricorian and Paul Klekotka and Johann Eli Gudj{\'o}nsson and James G. Krueger and Chris B. Russell},
  journal={The Journal of investigative dermatology},
  volume={133 1},
Although the histological changes seen in psoriasis have long been well characterized, the underlying cellular and molecular mechanisms have only begun to be elucidated over the past 20 years. Proinflammatory factors such as tumor necrosis factor (TNF)-α have a central role in psoriasis pathogenesis, and many T-helper 1 (Th1) cytokines and messenger RNAs are elevated in psoriatic lesions. IL-17A, IL-17F, and other Th17 cell-derived cytokines have been shown in murine models to induce features… CONTINUE READING
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