Chemokines as new inflammatory players in the pathogenesis of epilepsy
- Biology, MedicineEpilepsy Research
The role of inflammatory mediators in epilepsy: Focus on developmental and epileptic encephalopathies and therapeutic implications
- Psychology, MedicineEpilepsy Research
Immunity and Inflammation in Epilepsy.
- Medicine, PsychologyCold Spring Harbor perspectives in medicine
There is increasing knowledge supporting a role of specific inflammatory mediators and immune cells in the generation and recurrence of epileptic seizures, as well as in the associated neuropathology and comorbidities.
Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy
- Biology, MedicineThe Journal of Neuroscience
Together, the concerted action of adaptive and innate immunity triggered locally by intrahippocampal kainate injection contributes seizure-suppressant and neuroprotective effects, shedding new light on neuroimmune interactions in temporal lobe epilepsy.
The role of inflammation in the development of epilepsy
- Medicine, PsychologyJournal of Neuroinflammation
Understanding the neurobiology of inflammation in epileptogenesis will contribute to the development of new biomarkers for better screening of patients at risk for epilepsy and new therapeutic targets for both prophylaxis and treatment of epilepsy.
The Neuroinflammatory Role of Pericytes in Epilepsy
In vitro and in vivo studies have highlighted the potential of pericytes as a therapeutic target for seizure disorders, and it is shown that they respond more sensitively to proinflammatory cytokines than microglia and can also activatemicroglia.
Insights into inflammation and epilepsy from the basic and clinical sciences
- Biology, MedicineJournal of Clinical Neuroscience
Cytokines and Neurodegeneration in Epileptogenesis
- Biology, PsychologyBrain sciences
Increasing experimental and clinical data suggest the influence of peripheral inflammation on epileptogenesis, and studies focused on the molecular markers of neuroinflammation are of great value and may help deepen the knowledge about epilepsy, leading to the discovery of new drugs.
SHOWING 1-10 OF 88 REFERENCES
A role for leukocyte-endothelial adhesion mechanisms in epilepsy
- Medicine, BiologyNature Medicine
Leukocyte-endothelial interaction is suggested as a potential target for the prevention and treatment of epilepsy by showing that seizures induce elevated expression of vascular cell adhesion molecules and enhanced leukocytes rolling and arrest in brain vessels mediated by the leukocyte mucin P-selectin glycoprotein ligand-1.
Brain Inflammation in Epilepsy: Experimental and Clinical Evidence
- Biology, MedicineEpilepsia
The possibility that inflammation may be a common factor contributing, or predisposing, to the occurrence of seizures and cell death, in various forms of epilepsy of different etiologies is discussed.
Immunology: Barrier to electrical storms
- Biology, MedicineNature
A new study using two-photon fluorescence microscopy suggests cytotoxic T lymphocytes can be seen recruiting monocytes and neutrophils to the meninges at the blood–brain border, which raises new questions, including the mechanism of cell recruitment and how the cells produce such damage in meningitis.
Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation
- BiologyJournal of leukocyte biology
Actions of chemokines and the interaction with specific receptors go beyond their original, defined role of recruiting leukocytes to inflamed tissues and are proposed to propose novel functions ofChemokine receptors during demyelination/remyelination, and developmental processes.
Chemokines: a new class of neuromodulator?
- Biology, PsychologyNature Reviews Neuroscience
These findings, together with the pharmacological development of agonists and antagonists that are selective for chemokine receptors and can cross the blood–brain barrier, open a new era of research in neuroscience.
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy.
- BiologyBrain : a journal of neurology
It is suggested that the persistent leakage of serum IgG in the interstitial space and their uptake by neurons may participate in hypoperfusion and in neuronal dysfunction occurring in TLE.
Expression of Adhesion Factors Induced by Epileptiform Activity in the Endothelium of the Isolated Guinea Pig Brain In Vitro
- Biology, MedicineEpilepsia
In the present study, expression of inducible adhesion factors in brain endothelium was verified after pharmacological induction of seizure‐like activity in specific brain areas of the in vitro isolated guinea pig brain.
Pro-inflammatory cytokines and their effects in the dentate gyrus.
- BiologyProgress in brain research
TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis.
- Biology, MedicineBrain : a journal of neurology
It is proposed that the above-described cascade of events following common brain insults leads to brain dysfunction and eventually epilepsy and suggest TGF-betaRs as a possible therapeutic target.