The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene.

@article{Kelleher2010TheEP,
  title={The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene.},
  author={Fergal C. Kelleher and Ray McDermott},
  journal={European journal of cancer},
  year={2010},
  volume={46 13},
  pages={2357-68}
}
The anaplastic lymphoma kinase gene (ALK) is a gene on chromosome 2p23 that has expression restricted to the brain, testis and small intestine but is not expressed in normal lymphoid tissue. It has similarity to the insulin receptor subfamily of kinases and is emerging as having increased pathologic and potential therapeutic importance in malignant disease. This gene was originally established as being implicated in the pathogenesis of rare diseases including inflammatory myofibroblastic tumour… CONTINUE READING