The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer

@article{OHayre2013TheEM,
  title={The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer},
  author={Morgan O'Hayre and Jos{\'e} V{\'a}zquez-Prado and Irina Kufareva and Eric W. Stawiski and Tracy M. Handel and Somasekar Seshagiri and J. Silvio Gutkind},
  journal={Nature Reviews Cancer},
  year={2013},
  volume={13},
  pages={412-424}
}
Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of tumours carry activating mutations in GNAS (encoding Gαs), and that oncogenic activating mutations in genes encoding Gαq family members (GNAQ or GNA11) are present in ∼66% and ∼6% of melanomas arising in the eye and skin, respectively. Furthermore, nearly 20% of human tumours harbour mutations in GPCRs. Many human cancer… CONTINUE READING