The emerging landscape of breast cancer susceptibility

@article{Stratton2007TheEL,
  title={The emerging landscape of breast cancer susceptibility},
  author={Michael R. Stratton and Nazneen Rahman},
  journal={Nature Genetics},
  year={2007},
  volume={40},
  pages={17-22}
}
The genetic basis of inherited predisposition to breast cancer has been assiduously investigated for the past two decades and has been the subject of several recent discoveries. Three reasonably well-defined classes of breast cancer susceptibility alleles with different levels of risk and prevalence in the population have become apparent: rare high-penetrance alleles, rare moderate-penetrance alleles and common low-penetrance alleles. The contribution of each component to breast cancer… CONTINUE READING
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