The emerging family of dystrophin-related proteins.

  title={The emerging family of dystrophin-related proteins.},
  author={Derek J Blake and Jonathon M. Tinsley and K. E. Davies},
  journal={Trends in cell biology},
  volume={4 1},
Duchenne and Becker muscular dystrophies are caused by mutations in the gene encoding dystrophin, a component of the subsarcolemmal cytoskeleton. Dystrophin-related proteins are identical or homologous to the cysteine-rich and C-terminal domains of dystrophin. This part of dystrophin binds to a membrane-spanning glycoprotein complex in muscle. At least five dystrophin-related proteins are encoded by the Duchenne muscular dystrophy locus. These proteins are found in many non-muscle tissues where… CONTINUE READING