The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains.

@article{Luck2012TheEC,
  title={The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains.},
  author={Katja Luck and Sebastian Charbonnier and Gilles Trav{\'e}},
  journal={FEBS letters},
  year={2012},
  volume={586 17},
  pages={2648-61}
}
The canonical binding mode of PDZ domains to target motifs involves a small interface, unlikely to fully account for PDZ-target interaction specificities. Here, we review recent work on sequence context, defined as the regions surrounding not only the PDZ domains but also their target motifs. We also address the theoretical problem of defining the core of PDZ domains and the practical issue of designing PDZ constructs. Sequence context is found to introduce structural diversity, to impact the… CONTINUE READING