The emerging complexity of protein ubiquitination.

  title={The emerging complexity of protein ubiquitination.},
  author={David Komander},
  journal={Biochemical Society transactions},
  volume={37 Pt 5},
  • D. Komander
  • Published 1 October 2009
  • Biology
  • Biochemical Society transactions
Protein ubiquitination and protein phosphorylation are two fundamental regulatory post-translational modifications controlling intracellular signalling events. However, the ubiquitin system is vastly more complex compared with phosphorylation. This is due to the ability of ubiquitin to form polymers, i.e. ubiquitin chains, of at least eight different linkages. The linkage type of the ubiquitin chain determines whether a modified protein is degraded by the proteasome or serves to attract… 

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