The emerging clinical relevance of genomics in cancer medicine

  title={The emerging clinical relevance of genomics in cancer medicine},
  author={Michael F. Berger and Elaine R. Mardis},
  journal={Nature Reviews Clinical Oncology},
The combination of next-generation sequencing and advanced computational data analysis approaches has revolutionized our understanding of the genomic underpinnings of cancer development and progression. The coincident development of targeted small molecule and antibody-based therapies that target a cancer’s genomic dependencies has fuelled the transition of genomic assays into clinical use in patients with cancer. Beyond the identification of individual targetable alterations, genomic methods… CONTINUE READING