The emerging biology of the nitrite anion

@article{Gladwin2005TheEB,
  title={The emerging biology of the nitrite anion},
  author={Mark T. Gladwin and Alan N Schechter and Daniel B. Kim‐Shapiro and Rakesh P. Patel and Neil Hogg and Sruti S. Shiva and Richard O Iii Cannon and Malte Kelm and David A Wink and Michael Graham Espey and Edward H. Oldfield and Ryszard M. Pluta and Bruce A. Freeman and Jack R Jr Lancaster and Martin Feelisch and Jon O Lundberg},
  journal={Nature Chemical Biology},
  year={2005},
  volume={1},
  pages={308-314}
}
Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis. A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics. 

Copper and nitric oxide meet in the plasma

A new study shows that the multicopper oxidase ceruloplasmin is critical for maintaining plasma nitrite, revealing a new link between copper and nitric oxide homeostasis.

Nitrate and nitrite in biology, nutrition and therapeutics.

The latest advances in the understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.

NO generation from inorganic nitrate and nitrite: Role in physiology, nutrition and therapeutics

The nitrate-nitrite-NO pathway is emerging as a likely regulator of physiological functions in the gastrointestinal tract and in the cardiovascular system. In particular, it might serve as a backup

Nitrite reduction to nitric oxide in the vasculature.

through the continuous generation of vasoactive substances including nitric oxide (NO), prostaglandins, and endothelin, the vessel wall is actively involved in regulating blood flow in response to

Nitrate, nitrite and nitric oxide in gastric mucosal defense.

The human stomach normally contains high levels of bioactive nitric oxide (NO). This NO derives from salivary nitrate (NO3-) that is converted to nitrite (NO2-) by oral bacteria and thereafter non-

Nitric oxide release via oxygen atom transfer from nitrite at copper(ii).

A new pathway to release nitric oxide via oxygen atom transfer from nitrite at a copper(ii) site is reported.

Nitrite as regulator of hypoxic signaling in mammalian physiology

The mechanisms and properties of these various pathways and the role played by the local concentration of free oxygen in the affected tissue are discussed and additional direct signaling events not involving free nitric oxide are proposed.

The potential role of the red blood cell in nitrite-dependent regulation of blood flow.

There is evidence that erythrocyte haemoglobin is responsible for the oxygen-dependent reduction of nitrite to modulate blood flow and ongoing work focused on defining the precise mechanisms for export of NO activity from red blood cells and of other pathways that may mediate nitrite-dependent vasodilation is discussed.

Mechanisms of nitrite bioactivation.

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