The emergence of protocadherin-PC expression during the acquisition of apoptosis-resistance by prostate cancer cells

@article{Chen2002TheEO,
  title={The emergence of protocadherin-PC expression during the acquisition of apoptosis-resistance by prostate cancer cells},
  author={Min-Wei Chen and Francis Vacherot and Alexandre de la Taille and Sixtina Gil-Diez-de-Medina and Ruoqian Shen and Richard A. Friedman and Martin Burchardt and Dominique K. Chopin and Ralph Buttyan},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={7861-7871}
}
In order to identify gene products associated with the development of acquired therapeutic resistance by prostate cancer cells, we created two novel apoptosis-resistant prostate cancer cell lines, LNCaP-TR (phorbol-ester [TPA]-Resistant) and LNCaP-SSR (Serum Starvation-Resistant) by repeated transient exposure of cultured human LNCaP cells to apoptotic stimuli followed by expansion of surviving cell populations. These cell lines were found to be cross-resistant to the alternative selective… CONTINUE READING