The emergence of mouse models of atherosclerosis and their relevance to clinical research.

@article{Smith1997TheEO,
  title={The emergence of mouse models of atherosclerosis and their relevance to clinical research.},
  author={Jonathan D Smith and JanL. Breslow},
  journal={Journal of internal medicine},
  year={1997},
  volume={242 2},
  pages={
          99-109
        }
}
Due to the ability to introduce or mutate genes, the mouse has become the most common experimental animal model for atherosclerosis research. Wildtype mice on a chow diet do not get atherosclerosis. Three ways to induce atherosclerosis in mice are discussed: diet-induced, apoE deficiency-induced, and LDL receptor-deficiency induced. The atherosclerotic lesions in apoE-deficient mice have been well characterized, and they resemble human lesions in their sites of predilection and progression to… CONTINUE READING
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