The emergence of loss of efficacy during antidepressant drug treatment for major depressive disorder: An integrative review of evidence, mechanisms, and clinical implications

@article{Fornaro2019TheEO,
  title={The emergence of loss of efficacy during antidepressant drug treatment for major depressive disorder: An integrative review of evidence, mechanisms, and clinical implications},
  author={M. Fornaro and A. Anastasia and S. Novello and A. Fusco and Riccardo Pariano and D. De Berardis and M. Solmi and N. Veronese and B. Stubbs and E. Vieta and M. Berk and A. de Bartolomeis and A. Carvalho},
  journal={Pharmacological Research},
  year={2019},
  volume={139},
  pages={494–502}
}
&NA; The re‐emergence (i.e. ‘breakthrough’) of depressive symptoms despite maintenance treatment of depression with antidepressant drugs is a complex clinical phenomenon referred to as tolerance. Herein we critically appraise evidence from both pre‐clinical and clinical studies, focusing on putative mechanisms as well as clinical correlates and implications of the emergence tolerance during antidepressant treatment for major depressive disorder (MDD). It is firstly unclear to what extent this… Expand
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