The emergence and evolution of methicillin-resistant Staphylococcus aureus.

  title={The emergence and evolution of methicillin-resistant Staphylococcus aureus.},
  author={Keiichi Hiramatsu and Longzhu Cui and Makoto Kuroda and Teruyo Ito},
  journal={Trends in microbiology},
  volume={9 10},
Significant advances have been made in recent years in our understanding of how methicillin resistance is acquired by Staphylococcus aureus. Integration of a staphylococcal cassette chromosome mec (SCCmec) element into the chromosome converts drug-sensitive S. aureus into the notorious hospital pathogen methicilin-resistant S. aureus (MRSA), which is resistant to practically all beta-lactam antibiotics. SCCmec is a novel class of mobile genetic element that is composed of the mec gene complex… CONTINUE READING
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