The embryonic morphogen, Nodal, is associated with channel-like structures in human malignant melanoma xenografts.

@article{McAllister2010TheEM,
  title={The embryonic morphogen, Nodal, is associated with channel-like structures in human malignant melanoma xenografts.},
  author={Josephine C McAllister and Qian Zhan and Carsten Weishaupt and Mei-Yu Hsu and George Murphy},
  journal={Journal of cutaneous pathology},
  year={2010},
  volume={37 Suppl 1},
  pages={19-25}
}
Formation of channel-like structures, also termed vasculogenic mimicry (VM), describes the ability of aggressive melanoma cells to form PAS-positive anastomosing structures that correlate with tumor virulence. This phenomenon may indicate differentiation plasticity, a feature melanoma cells may share with stem cells in the developing embryo. Recent studies have indicated that VM and tumorigenicity of human malignant melanoma may depend on the signaling pathways of an embryonic morphogen, Nodal… CONTINUE READING

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