The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants.

@article{Karanjawala2002TheEL,
  title={The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants.},
  author={Zarir E. Karanjawala and Noritaka Adachi and Ryan A Irvine and Eui K Oh and Darryl Shibata and Klaus Schwarz and Chih-lin Hsieh and Michael R. Lieber},
  journal={DNA repair},
  year={2002},
  volume={1 12},
  pages={1017-26}
}
There are two general pathways by which multicellular eukaryotes repair double-strand DNA breaks (DSB): homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). All mammalian mutants in the NHEJ pathway demonstrate a lack of B and T lymphocytes and ionizing radiation sensitivity. Among these NHEJ mutants, the DNA-PK(cs) and Artemis mutants… CONTINUE READING