The embryo-fetal toxicity and teratogenic potential of ammonium perfluorooctanoate (APFO) in the rat.

@article{Staples1984TheET,
  title={The embryo-fetal toxicity and teratogenic potential of ammonium perfluorooctanoate (APFO) in the rat.},
  author={Robert E. Staples and B A Burgess and William David Kerns},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1984},
  volume={4 3 Pt 1},
  pages={429-40}
}
Ammonium perfluorooctanoate (APFO, greater than 95% pure) was administered to Sprague-Dawley rats from Days 6 through 15 of gestation by inhalation as a dust (whole body exposure) for 6 hr/day at 0, 0.1, 1, 10, and 25 mg/m3, or by gavage at 100 mg/kg body wt/day in corn oil. Maternal deaths occurred in the groups given the highest level of APFO by each route and overt toxicity was evident among the surviving dams of these groups and among those of the 10-mg/m3 group. The fetuses were examined… CONTINUE READING
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