The elusive link between LQT3 and Brugada syndrome: the role of flecainide challenge.

@article{Priori2000TheEL,
  title={The elusive link between LQT3 and Brugada syndrome: the role of flecainide challenge.},
  author={Silvia G. Priori and Carlo Napolitano and Peter J. Schwartz and R. Bloise and Lia Crotti and Elena Ronchetti},
  journal={Circulation},
  year={2000},
  volume={102 9},
  pages={
          945-7
        }
}
BACKGROUND Defects of the SCN5A gene encoding the cardiac sodium channel are associated with both the LQT3 subtype of long-QT syndrome and Brugada syndrome (BS). The typical manifestations of long-QT syndrome (QT interval prolongation) and BS (ST segment elevation in leads V1 through V3) may coexist in the same patients, which raises questions about the actual differences between LQT3 and BS. Intravenous flecainide is the standard provocative test used to unmask BS in individuals with concealed… CONTINUE READING

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