The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo.

@article{Keegan2002TheEF,
  title={The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo.},
  author={Brian Robert Keegan and Jessica L Feldman and Diana H Lee and David S. Koos and Robert K. Ho and Didier Y. R. Stainier and Deborah Yelon},
  journal={Development},
  year={2002},
  volume={129 7},
  pages={1623-32}
}
Precise temporal and spatial control of transcription is a fundamental component of embryonic development. Regulation of transcription elongation can act as a rate-limiting step during mRNA synthesis. The mechanisms of stimulation and repression of transcription elongation during development are not yet understood. We have identified a class of zebrafish mutations (pandora, sk8 and s30) that cause multiple developmental defects, including discrete problems with pigmentation, tail outgrowth, ear… CONTINUE READING
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