The elimination of accumulated and aggregated proteins: A role for aggrephagy in neurodegeneration

@article{Yamamoto2011TheEO,
  title={The elimination of accumulated and aggregated proteins: A role for aggrephagy in neurodegeneration},
  author={Ai Yamamoto and Anne Simonsen},
  journal={Neurobiology of Disease},
  year={2011},
  volume={43},
  pages={17-28}
}
The presence of ubiquitinated protein inclusions is a hallmark of most adult onset neurodegenerative disorders. Although the toxicity of these structures remains controversial, their prolonged presence in neurons is indicative of some failure in fundamental cellular processes. It therefore may be possible that driving the elimination of inclusions can help re-establish normal cellular function. There is growing evidence that macroautophagy has two roles; first, as a non-selective degradative… CONTINUE READING

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