The elevated expression of Th17-related cytokines and receptors is associated with skin lesion severity in early systemic sclerosis.

@article{Zhou2015TheEE,
  title={The elevated expression of Th17-related cytokines and receptors is associated with skin lesion severity in early systemic sclerosis.},
  author={Yan Zhou and Weikun Hou and Ke Xu and Dan Han and Congshan Jiang and Kuanhou Mou and Yue Li and Liesu Meng and Shemin Lu},
  journal={Human immunology},
  year={2015},
  volume={76 1},
  pages={22-9}
}
OBJECTIVE The objective was to survey the expression and localization of Th17-related cytokines and their correlation with skin lesion severity in early systemic sclerosis (SSc). METHODS The mRNA expression was detected by real-time quantitative polymerase chain reaction (RT-qPCR) from 21 SSc patients and 12 healthy controls (HC). The protein expression was examined by immunohistochemistry (IHC) and Western blotting. RESULTS The RT-qPCR analysis showed a significantly higher expression of… CONTINUE READING
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