The element(s) at the nontranscribed Xist locus of the active X chromosome controls chromosomal replication timing in the mouse.

@article{DiazPerez2005TheEA,
  title={The element(s) at the nontranscribed Xist locus of the active X chromosome controls chromosomal replication timing in the mouse.},
  author={Silvia V. Diaz-Perez and Y. S. Ouyang and Vanessa Christina Perez and Roxanna Cisneros and Moira Regelson and York Marahrens},
  journal={Genetics},
  year={2005},
  volume={171 2},
  pages={
          663-72
        }
}
In female mammalian cells, the inactive X chromosome is replicated late in S phase while the active X chromosome is replicated earlier. The replication times of the X chromosomes reflect a general trend in which late replication is associated with gene repression and earlier replication with transcriptional competence. The X-linked Xist gene is expressed exclusively from the inactive X chromosome where it is involved in the initiation and maintenance of X-inactivation. In contrast, no… CONTINUE READING

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