The electrostatic basis of Mg++ inhibition of transmitter release.

  title={The electrostatic basis of Mg++ inhibition of transmitter release.},
  author={Robert U. Muller and Alan Finkelstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={71 3},
The inhibition by Mg(++) of stimulus-evoked transmitter release is attributed to a decrease in surface potential, Psi(0), on the outer surface of the presynaptic terminal and hence a lower surface calcium concentration, [Ca(++)](0). Data on the frog neuromuscular junction are quantitatively fit by assuming that there is a negative charge density, sigma, on the outer surface of the presynaptic terminal of 6.5 x 10(13) charges per cm(2) and that simple diffuse double layer theory is applicable… CONTINUE READING

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