The electroneutral cation-chloride cotransporters.

  title={The electroneutral cation-chloride cotransporters.},
  author={David B. Mount and Eric Delpire and Gerardo Gamba and Anne E. Hall and Esteban Poch and Robert S. Hoover and Steven C. Hebert},
  journal={The Journal of experimental biology},
  volume={201 Pt 14},
Electroneutral cation-chloride cotransporters are widely expressed and perform a variety of physiological roles. A novel gene family of five members, encompassing a Na+-Cl- transporter, two Na+-K+-2Cl- transporters and two K+-Cl- cotransporters, encodes these membrane proteins; homologous genes have also been identified in a prokaryote and a number of lower eukaryotes. The cotransporter proteins share a common predicted membrane topology, with twelve putative transmembrane segments flanked by… CONTINUE READING