The electroneutral Na⁺:HCO₃⁻ cotransporter NBCn1 is a major pHi regulator in murine duodenum.

@article{Chen2012TheEN,
  title={The electroneutral Na⁺:HCO₃⁻ cotransporter NBCn1 is a major pHi regulator in murine duodenum.},
  author={Mingmin Chen and Jeppe Praetorius and Wen Yue Zheng and Fang Xiao and Brigitte Riederer and Anurag K. Singh and Nic{\'o}le Stieger and Jian Wang and Gary E. Shull and Christian Aalkjaer and Ursula Seidler},
  journal={The Journal of physiology},
  year={2012},
  volume={590 14},
  pages={
          3317-33
        }
}
Duodenocyte pHi control and HCO3 − secretion protects the proximal duodenum against damage by gastric acid. The molecular details of duodenocyte pH control are not well understood. A selective duodenal expression (within the upper GI tract) has been reported for the electroneutral Na+:HCO3 − cotransporter NBCn1 (Slc4a7). We aimed to determine the role of NBCn1 and NBCe2 in duodenocyte intracellular pH regulation as well as basal and agonist-stimulated duodenal bicarbonate secretion (JHCO3… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Similar Papers

Loading similar papers…