The elastic properties of valve interstitial cells undergoing pathological differentiation.

@article{Wyss2012TheEP,
  title={The elastic properties of valve interstitial cells undergoing pathological differentiation.},
  author={Kristine Wyss and Cindy Ying Yin Yip and Zahra Mirzaei and Xiaofan Jin and J. Chen and Craig A. Simmons},
  journal={Journal of biomechanics},
  year={2012},
  volume={45 5},
  pages={882-7}
}
Increasing evidence indicates that the progression of calcific aortic valve disease (CAVD) is influenced by the mechanical forces experienced by valvular interstitial cells (VICs) embedded within the valve matrix. The ability of VICs to sense and respond to tissue-level mechanical stimuli depends in part on cellular-level biomechanical properties, which may change with disease. In this study, we used micropipette aspiration to measure the instantaneous elastic modulus of normal VICs and of VICs… CONTINUE READING