The eicosanoids: a historical overview.

  title={The eicosanoids: a historical overview.},
  author={R. Roy Baker},
  journal={Clinical biochemistry},
  volume={23 5},
Eicosanoids are biologically active compounds derived from 20 carbon unsaturated fatty acids, among which arachidonic acid is a substrate of particular importance. The history of the eicosanoids dates back to the thirties, when new biologically active compounds were found in human seminal plasma. These "prostaglandins" were purified, and their structures and mechanisms of biosynthesis were elucidated in the early sixties. Other eicosanoids, including thromboxane A2, a potent platelet… CONTINUE READING