The efficiency of selenocysteine incorporation is regulated by translation initiation factors.


Selenocysteine (Sec) incorporation is an essential process required for the production of at least 25 human selenoproteins. This unique amino acid is co-translationally incorporated at specific UGA codons that normally serve as termination signals. Recoding from stop to Sec involves a cis-acting Sec insertion sequence element in the 3' untranslated region… (More)
DOI: 10.1016/j.jmb.2010.05.026