The efficiency of progesterone vaginal gel versus intramuscular progesterone for luteal phase supplementation in gonadotropin-releasing hormone antagonist cycles: a prospective clinical trial.

@article{Kahraman2010TheEO,
  title={The efficiency of progesterone vaginal gel versus intramuscular progesterone for luteal phase supplementation in gonadotropin-releasing hormone antagonist cycles: a prospective clinical trial.},
  author={Semra Kahraman and Serife Karagozoglu and Guvenç Karlikaya},
  journal={Fertility and sterility},
  year={2010},
  volume={94 2},
  pages={
          761-3
        }
}

Tables from this paper

Intramuscular progesterone (Gestone) versus vaginal progesterone suppository (Cyclogest) for luteal phase support in cycles of in vitro fertilization–embryo transfer: patient preference and drug efficacy
TLDR
Patients’ satisfaction and pregnancy rates were similar between vaginal and IM P supplementation, and there were no statistically significant differences in the patients’ characteristics and clinical outcomes between the two groups.
Evidence-Based Use of Progesterone During IVF
TLDR
There is now sufficient evidence to state that intravaginal progesterone preparations in therapeutic doses are equally efficacious and better tolerated by patients compared to traditional intramuscular progester one preparations.
Comparison of Vaginal Gel and Intramuscular Progesterone for In vitro Fertilization and Embryo Transfer with Gonadotropin-Releasing Hormone Antagonist Protocol
TLDR
Luteal support with VP had better clinical outcomes for young women undergoing IVF-ET with GnRH-antagonist protocol, and any statistically significant differences in ectopic pregnancy and abortion rates between two groups were not observed.
Patients’ administration preferences: progesterone vaginal insert (Endometrin®) compared to intramuscular progesterone for Luteal phase support
TLDR
It is suggested that PVI provides an easy-to-use and convenient method for providing the necessary luteal phase support for IVF cycles without the pain and inconvenience of daily IM PIO.
Luteal phase support in in vitro fertilization.
TLDR
Current evidence for efficacy, dosing, and timing of progesterone preparations as well as the role of hCG for luteal support in IVF cycles triggered with GnRH agonists are examined.
Comparing intramuscular progesterone, vaginal progesterone and 17 -hydroxyprogestrone caproate in IVF and ICSI cycle
TLDR
The use of intravaginal progesterone during the luteal phase in patients undergoing an IVF-ET program is suggested because of the low numbers of abortions, and high ongoing pregnancy rates.
Progesterone replacement with vaginal gel versus i.m. injection: cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts
STUDY QUESTION Does the type of luteal support affect pregnancy outcomes in recipients of vitrified blastocysts? SUMMARY ANSWER Luteal support with vaginal progesterone gel or i.m. progesterone (IMP)
Comparison of daily vaginal progesterone gel plus weekly intramuscular progesterone with daily intramuscular progesterone for luteal phase support in single, autologous euploid frozen-thawed embryo transfers
TLDR
Patient characteristics did not differ in LPS regimes and there were no significant differences in the rates of live birth, implantation, and clinical pregnancy between daily IMP and daily VP gel plus weekly IMHPC for LPS in single, autologous euploid FBTs after artificial EP.
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References

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TLDR
Crinone 8 is a good alternative to parental progesterone for luteal support in ART cycles and it is well tolerated but it is linked to an earlier appearance of menstrual flow in non conceptional cycles.
Luteal phase support in infertility treatment: a meta-analysis of the randomized trials.
TLDR
i.m. progesterone is favoured for luteal phase supplementation with the addition of estrogen in women undergoing IVF cycles, given the increased risk of ovarian hyperstimulation syndrome associated with hCG use.
Experience with progesterone gel for luteal support in a highly successful IVF programme.
TLDR
Crinone 8% offers an appreciable improvement, as it provides an effective luteal support option that avoids painful i.m. injections, and overall acceptability of Crinone 6% was excellent.
Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with rec
TLDR
Despite high P and E(2) concentrations during the early luteal phase in all three groups, luteolysis started prematurely, presumably because of excessive negative steroid feedback resulting in suppressed pituitary LH release.
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