The efficiency of antigen recognition by CD8+ CTL clones is determined by the frequency of serial TCR engagement.

@article{Hudrisier1998TheEO,
  title={The efficiency of antigen recognition by CD8+ CTL clones is determined by the frequency of serial TCR engagement.},
  author={Denis Hudrisier and Benedikt Kessler and Salvatore Valitutti and Curt M Horvath and Jean Charles Cerottini and Immanuel F. Luescher},
  journal={Journal of immunology},
  year={1998},
  volume={161 2},
  pages={553-62}
}
Using H-2Kd-restricted CTL clones, which are specific for a photoreactive derivative of the Plasmodium berghei circumsporozoite peptide PbCS(252-260) (SYIPSAEKI) and permit assessment of TCR-ligand interactions by TCR photoaffinity labeling, we have previously identified several peptide derivative variants for which TCR-ligand binding and the efficiency of Ag recognition deviated by fivefold or more. Here we report that the functional CTL response (cytotoxicity and IFN-gamma production… CONTINUE READING

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